Disulfides as Redox Switches: From Molecular Mechanisms to Functional Significance
نویسندگان
چکیده
منابع مشابه
Disulfides as redox switches: from molecular mechanisms to functional significance.
The molecular mechanisms underlying thiol-based redox control are poorly defined. Disulfide bonds between Cys residues are commonly thought to confer extra rigidity and stability to their resident protein, forming a type of proteinaceous spot weld. Redox biologists have been redefining the role of disulfides over the last 30-40 years. Disulfides are now known to form in the cytosol under condit...
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Thiol groups can undergo numerous modifications, making cysteine a unique molecular switch. Cysteine plays structural and regulatory roles as part of proteins or glutathione, contributing to maintain redox homeostasis and regulate signaling within and amongst cells. Not surprisingly therefore, cysteines are associated with many hereditary and acquired diseases. Mutations in the primary protein ...
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ژورنال
عنوان ژورنال: Antioxidants & Redox Signaling
سال: 2010
ISSN: 1523-0864,1557-7716
DOI: 10.1089/ars.2009.2510